Canada authorized the AstraZeneca vaccine.
The F.D.A.’s expert panel voted in favor of the Johnson & Johnson vaccine.
The Biden administration agreed to buy 100,000 doses of a combination antibody treatment for high-risk Covid-19 patients.
Get the latest updates here, as well as maps and vaccines in development.

The beginning of the end?

There’s been a lot of encouraging news about the pandemic lately, and as cases have plummeted across the United States, and the world, some people are beginning to wonder — is the end of the pandemic finally within sight?

My colleague Apoorva Mandavilli, who covers science for The Times, set out to answer this question and spoke to 21 experts about the future of the pandemic in the U.S.

“Just about all of them were optimistic about the mid- to long-term future, certainly about the summer,” Apoorva said. At the very least, most scientists say they now believe that the worst of the pandemic is behind us.

But Apoorva also told me the experts were concerned about the next few weeks and the high likelihood of a “fourth wave” of new cases.

Virus cases across the U.S. already appear to be leveling off from the steep decline that began in January, and the federal government warned governors today against relaxing pandemic control measures. Whether Americans will be able to beat back a possible coming wave depends on a number of unknowns:

Human behavior. “The biggest variable is behavior,” Apoorva said, “and it explains both why cases have fallen so much in most of the world, but also why they might go up again.”

Scientists say that cases have fallen in the U.S. largely because states imposed restrictions around the holidays, and — perhaps more important — people actually followed the rules. But now, as the outlook has improved, governors are lifting restrictions and are under enormous pressure to reopen even more broadly. If that happens, cases driven by the new variants are likely to explode.

Variants. Apoorva told me that the more contagious variants are causing a “pandemic within a pandemic.” “We have the larger pandemic — the thing we’ve been dealing with since last year — and that is winding to a close,” she said. “But in the meantime, these variants have created a new set of problems.”

The U.S. has been slow to track the spread of the variants, and the declining infection rates may be giving people a false sense of security. If the variants spread in the U.S., as they have elsewhere, they’ll most likely drive a surge in cases.

Vaccines. The vaccines have turned out to be more effective than anyone could have hoped, preventing serious illness and death in nearly all recipients so far. But scientists worry about the variants from South Africa and Brazil, which have been able to reinfect people who already had the original version of the virus. Still, if the Biden administration can keep its promise to immunize every American adult by the end of the summer — a tall order since many say they don’t want a dose — the variants should be no match for the vaccines.

Which leads us to the good news.

The experts predicted that the last surge would subside in the United States sometime in the early summer. By then, large outbreaks could be a thing of the past. Infections, hospitalizations and deaths may drop to negligible levels — and enough, hopefully, to be able to safely reopen the country.

“My kids won’t be vaccinated by the summer, so I’m not thinking that we will travel anywhere in a big way,” Apoorva said. “But I am looking forward to seeing friends, at least outdoors, and I’m looking forward to the numbers being low enough that we don’t all have to be so afraid when we go outside our homes.”
Suicides on the rise

For many people, the isolation of the pandemic opened a Pandora’s box of mental health issues, exacerbating the pressures on some of the most vulnerable members of society.

According to surveys of young Americans coming into emergency rooms, rates of suicidal thinking and behavior are up by 25 percent or more from similar periods in 2019.

In Japan, job losses, urban isolation and household burdens have compounded societal pressures, leading to a troubling spike in suicides by women.
Vaccine rollout

In the U.S., people are becoming less hesitant about getting vaccinated. According to a new survey, 55 percent of adults now say they have either received one dose or will get it as soon as they can, up from 34 percent in December.
In vaccine-hungry, cash-rich Europe, the hunt for more doses has nations trading with each other, weighing purchases from Russia and China and fielding offers from middlemen.
After the District of Columbia widened its criteria for vaccine eligibility, its registration system broke down when there was a surge in demand.
The president of Zimbabwe threatened to punish residents who do not take Covid vaccines.

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What else we’re following

Two British studies found that a single dose of the Pfizer vaccine is enough to provide robust protection from the coronavirus for people who have had Covid-19.
North Korea’s borders have been closed for a year because of the pandemic, but some Russian diplomats found a way home on a hand-powered railroad trolley.
President Jair Bolsonaro of Brazil railed against masks, even as the country faces record Covid deaths, a variant-fueled surge and lagging vaccinations.
The head of Canada’s largest pension fund stepped down after traveling to the United Arab Emirates to get vaccinated.
The New York Times